Genotoxic and mutagenic effects of erythrosine B, a xanthene food dye, on HepG2 cells

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Genotoxic and mutagenic effects of erythrosine B, a xanthene food dye, on HepG2 cells.

Erythrosine (ErB) is a xanthene and an US Food and Drug Administration approved dye used in foods, drugs and cosmetics. Although its utilization is permitted, ErB is described as inhibitor of enzymes and protein-protein interactions and is toxic to pituitary and spermatogenesis processes. However, the genotoxicity and mutagenicity of ErB is inconclusive in the literature. This study aimed to an...

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Male rats were treated of with a diet supplemented daily by the synthetic food colour erythrosine (0.08 and 0.4 g/kg diet) for 30 days. Changes in mutagenic activities, as an index for evaluating of possible toxic effects, were monitored by measuring chromosomal aberrations of rat bone marrow, nucleic acids and total protein concentrations of rat liver and brain. The present study found that er...

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ژورنال

عنوان ژورنال: Food and Chemical Toxicology

سال: 2012

ISSN: 0278-6915

DOI: 10.1016/j.fct.2012.07.042